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Original Research (Original Article) Open Access


Absence of attenuation in oxidative stress response with repeated lipid-rich feedings

Innocence I. Harvey, Sang-Rok Lee, Trint A. Gunnels, JohnHenry M. Schriefer, Richard J. Bloomer.

Abstract
Background: The study of postprandial oxidative stress has received considerable attention in recent years. Excess production of reactive oxygen and nitrogen species (RONS) in response to high fat feeding can lead to oxidative stress. However, repeated exposure to the same stressor may lead to attenuation in the oxidative stress response, possibly via an up-regulation in antioxidant enzyme activity.
Objective: To determine if repeated exposure to lipid-rich meal ingestion leads to a lower oxidative stress response over time, possibly due to an increase in antioxidant enzyme activity.
Methods: Sixteen healthy men consumed 10 high fat milkshakes over a 3+ week period. Blood was taken from subjects on the first day of each week (before and for 4 hours after milkshake ingestion) and analyzed for oxidative stress and antioxidant biomarkers.
Results: The oxidative stress response to repeated lipid-rich feeding was not different over time, as indicated by similar changes in plasma malondialdehyde and hydrogen peroxide, as well as superoxide dismutase, catalase and glutathione peroxidase activity.
Conclusion: These data indicate that RONS production is likely similar with repeated exposure to lipid-rich meals and does not induce an adaptive response within the blood antioxidant defense system in a way that is protective to cells.

Key words: Antioxidant enzymes; Postprandial; Reactive oxygen species; Triglycerides


 
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How to Cite this Article
Pubmed Style

Harvey II, Lee S, Gunnels TA, Schriefer JM, Bloomer RJ. Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. Oxid Antioxid Med Sci. 2014; 3(2): 83-90. doi:10.5455/oams.170414.or.062


Web Style

Harvey II, Lee S, Gunnels TA, Schriefer JM, Bloomer RJ. Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. http://www.oamsjournal.com/?mno=150631 [Access: January 23, 2018]. doi:10.5455/oams.170414.or.062


AMA (American Medical Association) Style

Harvey II, Lee S, Gunnels TA, Schriefer JM, Bloomer RJ. Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. Oxid Antioxid Med Sci. 2014; 3(2): 83-90. doi:10.5455/oams.170414.or.062



Vancouver/ICMJE Style

Harvey II, Lee S, Gunnels TA, Schriefer JM, Bloomer RJ. Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. Oxid Antioxid Med Sci. (2014), [cited January 23, 2018]; 3(2): 83-90. doi:10.5455/oams.170414.or.062



Harvard Style

Harvey, I. I., Lee, S., Gunnels, T. A., Schriefer, J. M. & Bloomer, R. J. (2014) Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. Oxid Antioxid Med Sci, 3 (2), 83-90. doi:10.5455/oams.170414.or.062



Turabian Style

Harvey, Innocence I., Sang-Rok Lee, Trint A. Gunnels, JohnHenry M. Schriefer, and Richard J. Bloomer. 2014. Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. Oxidants and Antioxidants in Medical Science, 3 (2), 83-90. doi:10.5455/oams.170414.or.062



Chicago Style

Harvey, Innocence I., Sang-Rok Lee, Trint A. Gunnels, JohnHenry M. Schriefer, and Richard J. Bloomer. "Absence of attenuation in oxidative stress response with repeated lipid-rich feedings." Oxidants and Antioxidants in Medical Science 3 (2014), 83-90. doi:10.5455/oams.170414.or.062



MLA (The Modern Language Association) Style

Harvey, Innocence I., Sang-Rok Lee, Trint A. Gunnels, JohnHenry M. Schriefer, and Richard J. Bloomer. "Absence of attenuation in oxidative stress response with repeated lipid-rich feedings." Oxidants and Antioxidants in Medical Science 3.2 (2014), 83-90. Print. doi:10.5455/oams.170414.or.062



APA (American Psychological Association) Style

Harvey, I. I., Lee, S., Gunnels, T. A., Schriefer, J. M. & Bloomer, R. J. (2014) Absence of attenuation in oxidative stress response with repeated lipid-rich feedings. Oxidants and Antioxidants in Medical Science, 3 (2), 83-90. doi:10.5455/oams.170414.or.062





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