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Original Research (Original Article) Open Access


Effect of papaya supplementation on oxidative stress markers in Parkinson's disease

Andrea Bolner, Rocco Micciolo, Ottavio Bosello, Giampietro Nordera.

Abstract
Objective: In Parkinson’s disease (PD), oxidative processes occur that are probably involved in the progression of neuronal damage. Recent studies suggest that regular consumption of antioxidant-rich foods or supplementation with functional foods like fermented papaya, may reduce cellular oxidative stress and protect against many age-related diseases by strengthening the physiological antioxidant barrier. Our study aims to assess the antioxidant properties of a commercial fermented papaya preparation (FPP) in PD by evaluation of its effects on a wide panel of oxidative stress markers in blood and urine.
Methods: A group of parkinsonian voluntary patients (T, n = 15) were treated 9 months with FPP and compared with a control group (NT, n = 12). The efficacy of FPP in increasing the physiological antioxidant barrier was evaluated at the times 0, 6 and 9 months with the analysis of 23 oxidative markers including total radical oxygen species, homocysteine, biological antioxidant potential, glutathione, superoxide dismutase, uric acid, total bilirubin, iron, ferritin, coenzyme Q10, 3-nitrotyrosine, total lipoperoxide, 4-hydroxy-nonenal, 8-hydroxydeoxyguanosine (8-OHdG) and 2-deoxyguanosine (2-dG).
Results: Among the considered markers, twenty not showed significant differences at times 0, 6 and 9 months between T and NT patients, demonstrating a consequent non-significant effect of FPP supplementation. Instead, three urinary markers of oxidative stress on nucleic acids, 8-OHdG/2-dG, 2-dG/uric acid and 2-dG/creatinine showed statistical significant interactions between ‘time’ and ‘treatment’, highlighting an effective better response to oxidative attack for T than NT.
Conclusions: Papaya supplementation for a medium-long time seems able to affect positively the turnover of oxidized nucleic acids helping to restore the normal nitrogenous bases into nucleotide chains and to replace those altered by radicals’ attack.

Key words: Oxidative stress markers, papaya, Parkinson’s disease


 
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How to Cite this Article
Pubmed Style

Bolner A, Micciolo R, Bosello O, Nordera G. Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. Oxid Antioxid Med Sci. 2016; 5(2): 49-55. doi:10.5455/oams.190416.or.096


Web Style

Bolner A, Micciolo R, Bosello O, Nordera G. Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. http://www.oamsjournal.com/?mno=222136 [Access: January 21, 2018]. doi:10.5455/oams.190416.or.096


AMA (American Medical Association) Style

Bolner A, Micciolo R, Bosello O, Nordera G. Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. Oxid Antioxid Med Sci. 2016; 5(2): 49-55. doi:10.5455/oams.190416.or.096



Vancouver/ICMJE Style

Bolner A, Micciolo R, Bosello O, Nordera G. Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. Oxid Antioxid Med Sci. (2016), [cited January 21, 2018]; 5(2): 49-55. doi:10.5455/oams.190416.or.096



Harvard Style

Bolner, A., Micciolo, R., Bosello, O. & Nordera, G. (2016) Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. Oxid Antioxid Med Sci, 5 (2), 49-55. doi:10.5455/oams.190416.or.096



Turabian Style

Bolner, Andrea, Rocco Micciolo, Ottavio Bosello, and Giampietro Nordera. 2016. Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. Oxidants and Antioxidants in Medical Science, 5 (2), 49-55. doi:10.5455/oams.190416.or.096



Chicago Style

Bolner, Andrea, Rocco Micciolo, Ottavio Bosello, and Giampietro Nordera. "Effect of papaya supplementation on oxidative stress markers in Parkinson's disease." Oxidants and Antioxidants in Medical Science 5 (2016), 49-55. doi:10.5455/oams.190416.or.096



MLA (The Modern Language Association) Style

Bolner, Andrea, Rocco Micciolo, Ottavio Bosello, and Giampietro Nordera. "Effect of papaya supplementation on oxidative stress markers in Parkinson's disease." Oxidants and Antioxidants in Medical Science 5.2 (2016), 49-55. Print. doi:10.5455/oams.190416.or.096



APA (American Psychological Association) Style

Bolner, A., Micciolo, R., Bosello, O. & Nordera, G. (2016) Effect of papaya supplementation on oxidative stress markers in Parkinson's disease. Oxidants and Antioxidants in Medical Science, 5 (2), 49-55. doi:10.5455/oams.190416.or.096





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